For Research Purposes Only

MOTS-c Peptide

Scientific Overview and benefits 
MOTS-c, a mitochondria-derived 16-amino-acid peptide, exhibits both cell-specific and hormonal functions, modulating AMP-activated protein kinase (AMPK) pathways to regulate metabolic stress responses and gene expression. It has been classified as a mitokine, influencing systemic metabolism through intracellular signaling.
Mechanism of Action
– Muscle Metabolism: Enhances insulin sensitivity, stimulates glucose transporters, and optimizes skeletal muscle adaptation via AMPK activation.
– Fat Cell Regulation: Modifies gene expression through mitonuclear communication, impacting antioxidant response elements (ARE) and metabolic pathways linked to glucose uptake and lipid utilization.
– Bone Formation: Regulates TGF-β/SMAD signaling, promoting osteogenic differentiation and bone density enhancement.
– Cardiovascular Influence: Correlates with endothelial function, potentially improving vascular reactivity via AMPK-mediated mechanisms.
– Cell Longevity: Interacts with aging regulators (NAD+, sirtuins) and exhibits a potential role in lifespan modulation.