SS-31

SS-31 (Elamipretide) is a synthetic tetrapeptide engineered to selectively target and protect mitochondria, particularly the inner mitochondrial membrane. It binds to cardiolipin, a critical phospholipid, thereby optimizing cytochrome c function within the electron transport chain. This interaction enhances electron flow, increases ATP synthesis, and reduces the generation of reactive oxygen species (ROS). SS-31 accumulates in mitochondria independently of cellular energy status and acts as a ROS scavenger, preventing mitochondrial damage and the release of pro-apoptotic factors such as cytochrome c. Its pharmacokinetic profile allows for both subcutaneous and oral administration, with favorable absorption and safety observed in preclinical studies.

Practical Benefits

• Boosts Cellular Energy: SS-31 helps cells make more energy by improving how mitochondria work.
• Protects Brain Cells: It may shield nerve cells from damage in diseases like Alzheimer’s, Parkinson’s, and after strokes.
• Supports Heart Health: SS-31 shows promise for people with heart failure and other heart problems by protecting heart cells.
• Helps Kidneys: It can protect kidneys from injury and age-related decline.
• May Slow Aging: By keeping mitochondria healthy, SS-31 could help slow down some effects of aging.