{"id":479,"date":"2026-10-24T20:18:50","date_gmt":"2026-10-24T20:18:50","guid":{"rendered":"https:\/\/wp310966.wpdns.ca\/?post_type=product&#038;p=479"},"modified":"2026-10-24T23:42:06","modified_gmt":"2026-10-24T23:42:06","slug":"pinealon","status":"publish","type":"product","link":"https:\/\/aminopurecanada.ca\/product-page\/pinealon\/","title":{"rendered":"Pinealon"},"content":{"rendered":"<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">Pinealon is peptide in Canada\u00a0Epithalon (Ala\u2013Glu\u2013Asp\u2013Gly) \u2014 Research\u2011Grade Tetrapeptide<\/span><\/p>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">Stricly for research purposes<\/span><\/p>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">Description<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: #ffffff; color: #213f95;\">Pinealon is a synthetic tripeptide \u2014 that means it\u2019s a very short chain of three amino acids linked by peptide bonds. Its well-accepted chemical sequence is:<\/span><\/p>\n<p><span style=\"background-color: #ffffff; color: #213f95;\">L-Glutamic acid \u2014 L-Aspartic acid \u2014 L-Arginine (often abbreviated Glu-Asp-Arg or EDR peptide)\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">Molecular specifics:<\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Chemical formula: C\u2081\u2085H\u2082\u2086N\u2086O\u2088\u00a0<\/span><\/li>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Structure: A linear peptide made of two acidic (Glu, Asp) and one basic (Arg) amino acids, giving it a mixed charge and high water solubility\u00a0<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: #ffffff; color: #213f95;\">Because of its small size (~390 Daltons) and polarity, Pinealon can cross biological membranes in cell-based models and is studied for potential intracellular activity .<\/span><\/p>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">Benefits and research use:<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: #ffffff; color: #213f95;\">Research into Pinealon focuses on several molecular and cellular processes:<\/span><\/p>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">1. Gene Expression \/ Nuclear Interaction<\/span><\/p>\n<ul>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Experimental studies suggest this peptide might interact with DNA or chromatin-associated proteins, influencing gene expression in neural cells under certain conditions\u00a0 .<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">2. Antioxidant \/ Redox Effects<\/span><\/p>\n<ul>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">In cell models, Pinealon has been shown to suppress reactive oxygen species (ROS) accumulation, which can stabilize oxidative stress pathways and promote cell survival under stress\u00a0 .<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">3. Neuroprotection &amp; Cell Survival<\/span><\/p>\n<ul>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Laboratory evidence indicates it might reduce apoptosis (programmed cell death) and enhance neuronal cell viability after oxidative stress or metabolic challenges\u00a0 .<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">4. Mitochondrial &amp; Metabolic Support<\/span><\/p>\n<ul>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Some research frameworks examine effects on mitochondrial membrane potential or cellular energy pathways, although these are primarily descriptive in vitro readouts\u00a0 .<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">5. Circadian &amp; Neuroendocrine Pathways (less well-established)<\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Some exploratory contexts associate Pinealon with regulation of sleep-wake cycles and factors like melatonin, though strong mechanistic evidence in humans is limited\u00a0 .<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">6. Preclinical Evidence &amp; Biological Findings<\/span><\/p>\n<p><span style=\"background-color: #ffffff; color: #213f95;\">Most documented research on Pinealon comes from non-clinical models (cell culture and animals):<\/span><\/p>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">7. Neuroprotective Effects<\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">In rat studies of prenatal stress (hyperhomocysteinemia), exposure to Pinealon improved offspring cognitive outcomes and enhanced neuron resistance to oxidative damage\u00a0 .<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">8. Cognitive Endpoints<\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Other animal experiments suggest improved memory, reduced neuronal cell death, and enhanced brain-related function after peptide administration\u00a0 .<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">9. Anti-aging Observations<\/span><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Some Russian studies categorize Pinealon as a \u201cbioregulator\u201d with potential geroprotective activity, meaning it may support physiological resistance to aging-related challenges in models of central nervous system dysfunction\u00a0 .<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">10. Potential Benefits Studied Research\u00a0<\/span><\/p>\n<p><span style=\"background-color: #ffffff; color: #213f95;\">Experimental and preliminary data suggest Pinealon may be associated with:<\/span><\/p>\n<ul>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Neuroprotection \u2014 less oxidative stress, enhanced neuronal survival in cell and animal models\u00a0<\/span><\/li>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Improved cognitive function \u2014 in rodent behavioral tests in select studies\u00a0<\/span><\/li>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Reduced cellular aging markers \u2014 proposed in gerontological research contexts\u00a0<\/span><\/li>\n<li><span style=\"background-color: #ffffff; color: #213f95;\">Potential circadian regulation \u2014 hypothesized linkage to pineal gland function and sleep-related processes\u00a0<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: bold; color: #213f95; background-color: #ffffff;\">\u00a0It\u2019s important to stress that these outcomes are from experimental, preclinical, or limited human contexts in the scientific literature. Large-scale clinical trials in humans to confirm effectiveness, safety, dosing, and therapeutic indications are not well established.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pinealon is peptide in Canada\u00a0Epithalon (Ala\u2013Glu\u2013Asp\u2013Gly) \u2014 Research\u2011Grade Tetrapeptide Stricly for research purposes Description &nbsp; Pinealon is a synthetic tripeptide [&hellip;]<\/p>\n","protected":false},"featured_media":487,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[19,18,17],"product_tag":[],"class_list":["post-479","product","type-product","status-publish","has-post-thumbnail","product_cat-atomizers","product_cat-capsules","product_cat-peptides","desktop-align-left","tablet-align-left","mobile-align-left","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/aminopurecanada.ca\/wp-json\/wp\/v2\/product\/479","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/aminopurecanada.ca\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/aminopurecanada.ca\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/aminopurecanada.ca\/wp-json\/wp\/v2\/comments?post=479"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/aminopurecanada.ca\/wp-json\/wp\/v2\/media\/487"}],"wp:attachment":[{"href":"https:\/\/aminopurecanada.ca\/wp-json\/wp\/v2\/media?parent=479"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/aminopurecanada.ca\/wp-json\/wp\/v2\/product_brand?post=479"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/aminopurecanada.ca\/wp-json\/wp\/v2\/product_cat?post=479"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/aminopurecanada.ca\/wp-json\/wp\/v2\/product_tag?post=479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}